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Understanding the 3D organization of cells, organelles and proteins in complex biological samples is the main goal for many fields of biology and medicine. Light scattering in these samples is the major limiting factor for achieving complete 3D information from organs (Richardson & Lichtman, 2015). Recent innovations in tissue clearing convert opaque tissues into translucent specimens, and has granted researchers the possibility to gaze deeper into their samples without performing arduous and likely damaging physical sectioning. High-resolution datasets for a comprehensive analysis of cells in the whole organs can be quickly acquired from intact samples employing optical sectioning fluorescence microscopy.
The aim of the platform is to provide user support for all phases of the large volume imaging workflow: tissue clearing, image acquisition using suitable microscopy methods for large sample volumes, and processing of the resulting massive amounts of data.
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