Spatial Biology

At the Center for Microscopy and Image analysis we provide user support for all phases of your spatial biology-multiplexing project : from experimental design, sample preparation to imaging and processing of the resulting data.

We also closely collaborate with the other technology platforms at the University of Zurich and will support you in finding the best technology that fits your spatial-omic research.

Currently we offer different instruments that are suitable for Spatial biology / Multiplexing workflows:

Akoya Vectra Polaris

MD ImageXpress

Zeiss Airy Scan 

A custom image processing pipeline for stitching and registering raw images in 3D can be found at:https://github.com/ZMB-UZH/zmb-ibex-jove

What multiplexing method are you interested in? At the ZMB we have worked with users to run 4i, HiFi, CODEX, and IBEX protocols on our existing infrastructure. The image above is from 5 rounds of 4i imaged on the Zeiss Airyscan confocal. Let's discuss how we can help you with your spatial biology project! 

Coming up in 2025...

The Lunaphore COMET- with RNAscope HiPlex for codetection of RNA and proteins (with seqIF)